Advances in the immunopathogenesis of multiple sclerosis yadav sk 1 mindur je ito k dhib jalbut s author information 1department of neurology rutgers robert wood johnson medical school piscataway new jersey 08854 usa purpose of review recent studies indicate a role for immune dysregulation in the pathogenesis of multiple sclerosis . Ultiple sclerosis including the impact of environmental risk factors on immunity in both multiple sclerosis and its animal models recent findings cd4 t helper th cells have long been implicated as the main drivers of pathogenesis of multiple sclerosis however current studies indicate that multiple sclerosis is largely a heterogeneous disease process which involves both innate and . Therefore b cells cd8 t cells and microglia macrophages can also play an important role in the immunopathogenesis of multiple sclerosis apart from proinflammatory cd4 th1 th17 cell subsets. Pa muraro a lugaresi d gambi many of the pathological aspects of multiple sclerosis ms lesions have been known for over a century it is only recently however that different patterns of demyelination have been linked to distinct pathways of immune mediated tissue destruction. Advances in the immunopathogenesis of multiple sclerosis editors gambi domencio lugaresi allesandra muraro paolo a eds free preview
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